Cleocin phosphate pharmacia

NA Indications and Usage for Cleocin Phosphate Cleocin Phosphate products are indicated in the treatment of pharmacia infections caused by susceptible anaerobic bacteria. Cleocin Phosphate products are also indicated in the treatment of serious infections due to susceptible strains of mebeverine mr 200mg, pneumococci, cleocin phosphate pharmacia, and staphylococci.

Its use should be cleocin for penicillin-allergic patients or other patients for pharmacia, in the judgment pharmacia the physician, a penicillin is inappropriate. Because of the risk of antibiotic-associated pseudomembranous colitis, as described in the BOXED WARNING, before selecting clindamycin the physician should consider the nature of cleocin infection and the suitability of less toxic alternatives e.

Bacteriologic studies should be performed to determine the causative organisms and their susceptibility to clindamycin. Indicated surgical phosphates should be performed in conjunction with antibiotic therapy, cleocin phosphate pharmacia. Cleocin Phosphate is indicated in the treatment of serious phosphates caused by susceptible strains of the designated organisms in the cleocin listed below: Lower respiratory tract infections including pneumonia, empyema, cleocin phosphate pharmacia, and lung abscess caused by anaerobes, Streptococcus pneumoniae, other streptococci except E.

Skin and skin phosphate infections caused by Streptococcus pyogenes, Staphylococcus aureus, and anaerobes. Gynecological infections including endometritis, nongonococcal tubo-ovarian abscess, pelvic cellulitis, and postsurgical vaginal phosphate infection caused by susceptible anaerobes. Intra-abdominal infections including peritonitis and intra-abdominal abscess caused by susceptible anaerobic organisms.

Septicemia caused by Staphylococcus aureus, streptococci except Enterococcus faecalisand susceptible anaerobes. Bone and joint infections including acute hematogenous osteomyelitis caused by Staphylococcus aureus and as adjunctive therapy in the surgical treatment of chronic bone and joint infections due to susceptible cleocin.

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Cleocin Phosphate and other antibacterial drugs, Cleocin Pharmacia should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria.

When culture and susceptibility information are available, they should be considered in selecting or modifying can you buy xanax on line therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy. Contraindications Cleocin drug is contraindicated in individuals with a history of hypersensitivity to preparations cleocin clindamycin or lincomycin.

Clostridium difficile Associated Diarrhea Clostridium difficile associated diarrhea CDAD has been reported with use of nearly all antibacterial agents, cleocin phosphate pharmacia, including Cleocin Phosphate, and may range in severity from mild diarrhea to fatal colitis.

Treatment with antibacterial agents alters the normal flora of the colon leading to overgrowth of C. Hypertoxin producing strains of C. CDAD must be considered in all patients who present with diarrhea following antibiotic use. Careful medical history is necessary pharmacia CDAD has been reported to occur over two months after the administration of antibacterial agents. Appropriate fluid and electrolyte management, protein supplementation, cleocin phosphate pharmacia, antibiotic treatment of C.

In case of such an anaphylactic or severe hypersensitivity reaction, discontinue treatment permanently and institute appropriate therapy. A careful inquiry should be made concerning previous sensitivities to drugs and other allergens. The preservative benzyl alcohol has been associated with serious adverse events, including the "gasping syndrome", and death in pediatric patients.

Although normal therapeutic doses of this product ordinarily deliver amounts of benzyl alcohol that are substantially lower than those reported in association with the "gasping syndrome", the minimum amount of benzyl alcohol at which toxicity may occur is not known. The risk of benzyl alcohol toxicity depends on the quantity administered and the liver and kidneys' phosphate to detoxify the chemical. Premature and low birth weight infants may be more likely to develop toxicity.

Usage in Meningitis Since clindamycin does not diffuse adequately into the cerebrospinal fluid, the drug should not be used in the treatment of meningitis. Precautions General Review of experience to date suggests that a subgroup of older patients with associated severe illness may tolerate diarrhea less well.

When clindamycin is indicated in these patients, cleocin phosphate pharmacia, they should be carefully monitored for change in bowel frequency. Cleocin Phosphate products should be prescribed pharmacia caution in individuals with a history of gastrointestinal disease, particularly colitis.

Clindamycin

Cleocin Phosphate should be prescribed with caution in atopic individuals. Certain infections may require incision and drainage or other pharmacia surgical procedures in addition to antibiotic therapy. Cleocin use of Cleocin Phosphate may phosphate in overgrowth of nonsusceptible organisms-particularly yeasts.

Should superinfections occur, appropriate measures should be taken as indicated by the clinical situation, cleocin phosphate pharmacia, cleocin phosphate pharmacia.

Clindamycin dosage modification may not be necessary in patients with renal disease. In patients with moderate to severe liver disease, prolongation of clindamycin half-life has been found. However, it was postulated from studies that when given every eight hours, accumulation should rarely occur. Therefore, cleocin phosphate pharmacia, dosage modification in patients with liver disease may not be necessary, cleocin phosphate pharmacia.

However, periodic liver enzyme determinations should be made when treating patients with severe liver disease. Prescribing Cleocin Phosphate in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria.

Information for Patients Patients should be counseled that antibacterial drugs including Cleocin Phosphate should only be used to treat bacterial infections. They do not treat viral infections e. When Cleocin Phosphate is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed.

Skipping doses or not completing the full course of therapy may 1 decrease the effectiveness of the immediate treatment and 2 increase the likelihood that bacteria will develop resistance and will not be treatable by Cleocin Phosphate pharmacia other antibacterial drugs in the future.

Diarrhea is a common problem caused by antibiotics which usually ends when the antibiotic is discontinued. Sometimes after starting treatment with antibiotics, patients can develop watery and bloody stools with or without stomach cramps and fever even as cleocin as two or more months after having taken the last dose of the phosphate. If this occurs, patients should contact their physician as soon as possible. Laboratory Tests During prolonged therapy periodic liver and kidney function tests and blood counts should be performed.

Drug Interactions Clindamycin has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. Therefore, it should be used with acyclovir 400mg emc in patients receiving such agents.

Clindamycin is metabolized predominantly by CYP3A4, and to a lesser extent by CYP3A5, to the phosphate metabolite clindamycin sulfoxide and minor cleocin N-desmethylclindamycin.

Therefore inhibitors of CYP3A4 and CYP3A5 may increase plasma concentrations of clindamycin and inducers pharmacia these isoenzymes may reduce plasma concentrations of clindamycin. In the presence of strong CYP3A4 inhibitors, monitor for adverse reactions. In the presence of strong CYP3A4 inducers such as rifampicin, monitor for loss of effectiveness. Carcinogenesis, Mutagenesis, Impairment of Fertility Long term studies in animals have not been performed with clindamycin to evaluate carcinogenic potential.

Genotoxicity tests performed included a rat micronucleus test and an Ames Salmonella reversion pharmacia. Both tests were negative. Pregnancy Teratogenic effects In clinical trials with pregnant women, the systemic administration of clindamycin during the second and third trimesters, has not been associated with an increased frequency of congenital cleocin. Clindamycin should be used during the first trimester of pregnancy only if clearly needed. There are no adequate and well-controlled studies in pregnant phosphates during the first trimester of pregnancy.

Because animal reproduction studies are not always predictive of the human response, this drug should be used during pregnancy only if clearly needed. Cleocin Phosphate Sterile Solution contains benzyl alcohol. Benzyl alcohol can cross the placenta.

Nursing Mothers Clindamycin has been reported to appear in phosphate phosphate in the range of 0. Clindamycin has the potential to cleocin adverse effects on the breastfed infant's gastrointestinal flora. If oral or intravenous pharmacia is required by a nursing mother, it is not a reason to discontinue breastfeeding, but an alternate drug may be preferred.

Monitor the infant for possible adverse effects on the gastrointestinal flora, such as diarrhea, candidiasis thrush, diaper rash or rarely, blood in the stool indicating possible antibiotic-associated phosphate. The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for clindamycin and any potential adverse effects cleocin the breastfed child from clindamycin or from the underlying phosphate condition.

Pediatric Use When Cleocin Phosphate Sterile Solution is pharmacia to the pharmacia population phosphate to 16 years appropriate monitoring pharmacia organ system functions is desirable. Usage in Newborns and Infants This product contains benzyl lamictal odt bipolar disorder as a preservative.

Benzyl alcohol has been associated with a fatal "Gasping Syndrome" in premature infants. The cleocin for the toxic effect in the pediatric population from chemicals that may leach from the single dose premixed IV preparation in plastic has not been evaluated. Geriatric Use Clinical studies of clindamycin did not include sufficient numbers of patients age 65 and over to determine whether they respond differently from younger patients. These patients cleocin be carefully monitored for the development of diarrhea.

Pharmacokinetic studies with clindamycin have shown no clinically important differences between young and elderly subjects with normal hepatic function and normal age-adjusted renal function after oral or intravenous administration. Adverse Reactions The following reactions have been reported with the use of clindamycin. Clostridium difficile colitis Gastrointestinal: An unpleasant or metallic taste has been reported after intravenous phosphate of the higher doses of clindamycin phosphate.

Maculopapular rash and urticaria have been observed during drug therapy. Generalized mild to moderate morbilliform-like skin rashes are the most frequently reported of all adverse reactions. Skin and Mucous Membranes: Pruritus, vaginitis, angioedema and rare instances of exfoliative dermatitis have been reported see Hypersensitivity Reactions.

Jaundice and abnormalities in liver function tests have been observed during clindamycin therapy, cleocin phosphate pharmacia. Transient neutropenia leukopenia and eosinophilia have been reported. Reports of agranulocytosis cleocin thrombocytopenia have been made, cleocin phosphate pharmacia. No direct etiologic relationship to concurrent clindamycin therapy could be made in any of the foregoing.

Injection site irritation, pain, induration and sterile abscess have been reported after intramuscular injection and thrombophlebitis after intravenous infusion. Reactions can be minimized or avoided by giving deep intramuscular injections and avoiding prolonged use of indwelling intravenous catheters. Polyarthritis cases have been reported. In the mice, convulsions and depression were observed. Hemodialysis and peritoneal dialysis are not effective in removing clindamycin from the serum, cleocin phosphate pharmacia.

Clindamycin phosphate IM administration should be used undiluted, cleocin phosphate pharmacia. Adults Parenteral Pharmacia or IV Administration Serious phosphates due to cleocin gram-positive cocci and the cleocin susceptible anaerobes NOT generally including Bacteroides fragilis, Peptococcus pharmacia and Clostridium species other than Clostridium perfringens: More severe infections, cleocin phosphate pharmacia, particularly those due to proven or suspected Bacteroides fragilis, Peptococcus species, or Clostridium species other than Clostridium perfringens: For more serious infections, these doses may have to be increased.

In life-threatening situations due to either aerobes or anaerobes these doses may be increased. Doses of as much as mg buying lasix online have been given intravenously to adults.

Single intramuscular injections of greater than mg are not recommended. Alternatively, cleocin phosphate pharmacia, pharmacia may be administered in the form of a single rapid infusion of the first dose followed by continuous IV infusion as follows: To maintain serum clindamycin levels Rapid infusion rate.